Joseph Tsai, MD, PhD

Joseph Tsai, MD, PhD, is a board-certified radiation oncologist with expertise in stereotactic body radiotherapy, stereotactic radiosurgery and image-guided radiotherapy. He treats a wide array of cancers including cancer of the central nervous system, head and neck, lung, breast, genitourinary system and gastrointestinal organs, as well as sarcomas, lymphomas and metastatic disease. In addition, Dr. Tsai has a special interest and expertise in evidence appraisal.

Away from work Dr. Tsai enjoys spending time with his wife, playing musical instruments, singing with the Seattle Symphony Chorale, playing tabletop games, and sports.

• MultiCare Oncology Group

• American Society for Radiation Oncology
• American College of Radiology

• Thonglert K, Apisarnthanarax S, Yeap BY, Havard ME, Schaub SK, Nyflot MJ, Bowen SR, He Y, Tsai J, De BS, Chamseddine I, Pursley J, Roberts H, Wo J, Prayongrat A, Alisanant P, Amornwichet N, Khorprasert C, Hong T, Koay EJ, Grassberger C. Establishing Albumin-Bilirubin Score Changes as Predictors of Radiation-Induced Liver Disease in Hepatocellular Carcinoma Patients Post-External Beam Radiation Therapy. Int J Radiat Oncol Biol Phys. 2026 Jun 1;125(2):481-488. doi: 10.1016/j.ijrobp.2025.11.009. Epub 2025 Nov 15. PMID: 41248759.
• Tsai J, Grassberger C, Nyflot MJ, Thonglert K, Zaki P, Nguyen MH, Schaub SK, Apisarnthanarax S, Bowen SR. Functional liver imaging and dosimetry for risk stratification in patients with hepatocellular carcinoma undergoing radiotherapy: validation study. Radiother Oncol. 2025 Aug;209:110963. doi: 10.1016/j.radonc.2025.110963. Epub 2025 May 31. PMID: 40456294.
• Thonglert K, Tsai J, Monsky WL, Anderson AC, Grassberger C, Bowen SR, Nyflot MJ, He Y, Zaki P, Johnson GE, Apisarnthanarax S. Safety and Efficacy of External Beam Radiation Therapy in Hepatocellular Carcinoma Patients Previously Treated With Yttrium 90 Transarterial Radioembolization. Adv Radiat Oncol. 2025 Dec 27;11(3):101984. doi: 10.1016/j.adro.2025.101984. PMID: 41684461; PMCID: PMC12890703.
• Thonglert K, Greer MD, Schaub SK, Bowen SR, Menghini AM, Nyflot MJ, Grassberger C, Tsai J, Zaki P, Kim EY, Wong T, Apisarnthanarax S. Simultaneous integrated boost and protection proton beam therapy approach for hepatocellular carcinoma. Clin Transl Radiat Oncol. 2025 Jul 1;54:101008. doi: 10.1016/j.ctro.2025.101008. PMID: 40778089; PMCID: PMC12328680.
• Newell KR, Ferguson-Steele ZO, Shin D, Noh MG, Pipavath S, Tsai J, Hendrickson K, Gutschenritter T, Kang J. Radiation Dose Overlay Improves Radiologists' Interpretation of Post-therapy Computed Tomography Imaging for Thoracic Malignancies. Adv Radiat Oncol. 2025 Sep 13;10(12):101899. doi: 10.1016/j.adro.2025.101899. PMID: 41333183; PMCID: PMC12666695.
• Anderson AC, Ho J, Hall ET, Hannan R, Liao JJ, Louie AV, Ma TM, Psutka SP, Rengan R, Siva S, Swaminath A, Tachiki L, Tang C, Teh BS, Tsai J, Tykodi SS, Weg E, Zaorsky NG, Lo SS. Focal therapy for oligometastatic and oligoprogressive renal cell carcinoma: a narrative review. Future Oncol. 2024;20(33):2573-2588. doi: 10.1080/14796694.2024.2389769. Epub 2024 Sep 11. PMID: 39258792; PMCID: PMC11534104.
• Zaki P, Thonglert K, Apisarnthanarax S, Grassberger C, Bowen SR, Tsai J, Sham JG, Chiang BH, Nyflot MJ. Liver injury and recovery following radiation therapy for hepatocellular carcinoma: insights from functional liver imaging. Hepatoma Res. 2024;10:36. doi: 10.20517/2394-5079.2024.27. Epub 2024 Sep 8. PMID: 40353184; PMCID: PMC12064179.
• Tsai J, Vellayappan B, Venur V, McGranahan T, Gray H, Urban RR, Tseng YD, Palmer J, Foote M, Mayr NA, Combs SE, Sahgal A, Chang EL, Lo SS. The optimal management of brain metastases from gestational trophoblastic neoplasia. Expert Rev Anticancer Ther. 2022 Mar;22(3):307-315. doi: 10.1080/14737140.2022.2038566. Epub 2022 Feb 13. PMID: 35114862.
• Tsai J, Lo SS. Stereotactic radiosurgery and hypofractionated stereotactic radiotherapy for gliomas. Intracranial Stereotactic Radiosurgery, 3rd Edition, Sheehan JP and Lunsford LD (editors), CRC Press. 2021

My philosophy is to work with you and your loved ones to make treatment decisions that give you the best ability to beat cancer while carefully considering your beliefs and values. To do this, I strive to provide the most clear and up-to-date information available about what you’re going through, and my goal is to lead your treatment team in giving you the most excellent and compassionate care possible.